منابع مشابه
Peripherally-acting opioids.
Opioids are broad-spectrum analgesics with potent pain-relieving qualities but also with potential adverse effects related to both short-term and long-term therapy. Researchers have attempted to alter existing opioid analgesics, utilize different routes/formulations, or combine opioid analgesics with other compounds in efforts to improve analgesia while minimizing adverse effects. Exogenous opi...
متن کاملTargeting pain and inflammation by peripherally acting opioids
INTRODUCTION Opioids can produce potent analgesia by activating opioid receptors outside the central nervous system, thus avoiding centrally mediated unwanted effects. Peripheral opioid receptors are expressed in peripheral sensory (dorsal root ganglion) neurons and can interact with exogenous or endogenous opioid ligands both in animals and in humans. Inflammation of peripheral tissue leads to...
متن کاملPeripherally acting opioids and clinical implications for pain control.
Opioid receptors are widely expressed in the central and peripheral nervous system and in the non-neuronal tissues. Data from animal and human clinical studies support the involvement of peripheral opioid receptors in analgesia, especially in the presence of inflammation. Inflammation has been shown to increase the synthesis of opioid receptors in the dorsal root ganglion neurons and enhance tr...
متن کاملTopical and peripherally acting analgesics.
Acute nociceptive, inflammatory, and neuropathic pain all depend to some degree on the peripheral activation of primary sensory afferent neurons. The localized peripheral administration of drugs, such as by topical application, can potentially optimize drug concentrations at the site of origin of the pain, while leading to lower systemic levels and fewer adverse systemic effects, fewer drug int...
متن کاملAre Long-Acting Opioids More Effective Than Short-Acting Opioids for Chronic Pain?
A new study calls into question the view that extended-release/long-acting (ER/LA) opioids are more effictive than immediate-release/short-acting (IR/SA) formulations for the management of chronic pain.1 The acceptance of the purported benefits of ER/LA opioids is understandable for patients whose pain is continuous and fairly constant over the course of the day. As an accompanying editorial to...
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ژورنال
عنوان ژورنال: March 2008
سال: 2008
ISSN: 2150-1149,1533-3159
DOI: 10.36076/ppj.2008/11/s121